I compared 2 HTML5/CSS/JS frameworks and decided to use bootsrap - http://getbootstrap.com/.
The other framework called Foundation http://foundation.zurb.com/ provided similar features but the documentation was better on bootstrap and it seems to have a broader support in web tools (like apache wicket or google web toolkit).
I started to integrate bootstrap into plain web pages, enhanced by some very basic PHP scripting. Beside plain HTML pages bootstrap is very easy to be used in google web toolkit / app engine.
The migration from version 2 to version 3 has several manual migration tasks involved and if you customize your bootstrap there is no easy way to keep your settings (like colors, ...).
But overall it makes it very easy to create web pages to run on any device.